Opioids can result in sleep-relevant respiration Conditions such as central rest apnea (CSA) and slumber-similar hypoxemia; opioid use will increase danger of CSA inside a dose-dependent vogue; in individuals who current with CSA, take into account decreasing opioid dosage working with ideal practices for opioid taper
No significant interaction is predicted with concurrent utilization of opioid analgesics and alvimopan in patients who been given opioid analgesics for seven or fewer consecutive times just before alvimopan.
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Look at prescribing naloxone, determined by the patient's threat variables for overdose, such as concomitant utilization of CNS depressants, a record of opioid use condition, or prior opioid overdose.
If opioid use is necessary for an extended time period inside a Expecting lady, advise the patient of the potential risk of neonatal opioid withdrawal syndrome, which may be lifestyle-threatening Otherwise acknowledged and addressed. Make sure management by neonatology specialists will be out there at shipping. (5.five)
Use of opioid analgesics for extended time frame all through pregnancy may trigger neonatal opioid withdrawal syndrome; there aren't any accessible details on pregnant Ladies to tell a drug-associated hazard for big beginning defects and miscarriage
The pharmacokinetics of hydromorphone in people with significant hepatic impairment hasn't been analyzed. An extra boost in Cmax and AUC of hydromorphone in this group is anticipated and will be taken into consideration when picking out a setting up dose [see Medical Pharmacology (twelve.three)].
When the response to an opioid antagonist is suboptimal or only brief in character, administer click here extra antagonist as directed through the product or service's prescribing info.
diazepam intranasal and hydromorphone both equally maximize sedation. Keep away from or Use Alternate Drug. Limit use to individuals for whom option cure alternatives are insufficient
Ensure precision when prescribing, dispensing, and administering DILAUDID Oral Option more info to stop dosing faults on account of confusion among mg and mL, which could lead to accidental overdose and Demise.
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Although the danger of addiction in almost any particular person is mysterious, it could possibly arise in people properly prescribed DILAUDID Oral Resolution or DILAUDID Tablets. Addiction can occur at recommended dosages and Should the drug is misused or abused.
buprenorphine, lengthy-acting injection and hydromorphone each increase sedation. Avoid or Use Alternate Drug. Restrict use to sufferers for whom substitute procedure alternatives are inadequate
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